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The portal vein or hepatic portal vein ( HPV) is a that carries from the gastrointestinal tract, , and to the . This blood contains and extracted from digested contents. Approximately 75% of total liver blood flow is through the portal vein, with the remainder coming from the hepatic artery proper. The blood leaves the liver to the heart in the .

The portal vein is not a true , because it conducts blood to beds in the liver and not directly to the heart. It is a major component of the hepatic portal system, one of three portal venous systems in the human body; the others being the hypophyseal and renal portal systems.

The portal vein is usually formed by the confluence of the superior mesenteric, , inferior mesenteric, left, right gastric veins and the .

Conditions involving the portal vein cause considerable illness and death. An important example of such a condition is elevated in the portal vein. This condition, called portal hypertension, is a major complication of . In abdominal obesity fats, inflammatory and other toxic substances are transported by the portal vein from visceral fat into the liver, leading to insulin resistance and metabolic dysfunction–associated steatotic liver disease.


Structure
Measuring approximately 8 cm (3 inches) long in adults,
(2025). 9780781771740, Wolters Kluwer Health/Lippincott Williams & Wilkins. .
the portal vein is located in the right upper quadrant of the abdomen, originating behind the neck of the .

In most individuals, the portal vein is formed by the union of the superior mesenteric vein and the .

(2025). 9781550093643, PMPH-USA.
For this reason, the portal vein is occasionally called the splenic-mesenteric confluence.
(2025). 9783540657972, Springer.
Occasionally, the portal vein also directly communicates with the inferior mesenteric vein, although this is highly variable. Other tributaries of the portal vein include the and the left and right gastric veins. and also pararumbilical vein and prepyloric vein.

+ Tributaries of the hepatic portal vein

Immediately before reaching the liver, the portal vein divides into right and left. It ramifies further, forming smaller venous branches and ultimately portal venules. Each portal venule courses alongside a hepatic arteriole and the two vessels form the vascular components of the . These vessels ultimately empty into the to supply blood to the liver.


Portacaval anastomoses
The portal venous system has several with the systemic venous system. In cases of portal hypertension these anastomoses may become engorged, dilated, or varicosed and subsequently rupture.


Accessory hepatic portal veins
Accessory hepatic portal veins are those veins that drain directly into the liver without joining the hepatic portal vein. These include the paraumbilical veins as well as veins of the , falciform ligament, and those draining the wall.


Function
The portal vein and form the liver's dual blood supply. Approximately 75% of hepatic blood flow is derived from the portal vein, while the remainder is from the hepatic arteries.

Unlike most veins, the portal vein does not drain into the . Rather, it is part of a portal venous system that delivers venous blood into another , the of the liver. In carrying venous blood from the tract to the liver, the portal vein accomplishes two tasks: it supplies the liver with metabolic substrates and it ensures that substances ingested are first processed by the liver before reaching the systemic circulation. This accomplishes two things. First, possible toxins that may be ingested can be detoxified by the hepatocytes before they are released into the systemic circulation. Second, the liver is the first organ to absorb nutrients just taken in by the . After draining into the liver , blood from the liver is drained by the .


Clinical significance

Portal hypertension
Increased in the portal vein, called portal hypertension, is a major complication of liver disease, most commonly .
(2025). 9780632055821, Blackwell Science.
A dilated portal vein (diameter of greater than 13 or 15 mm) is a sign of portal hypertension, with a sensitivity estimated at 12.5% or 40%. On Doppler ultrasonography, the main portal vein (MPV) peak systolic velocity normally ranges between 20 cm/s and 40 cm/s. A slow velocity of <16 cm/s in addition to dilatation in the MPV are diagnostic of portal hypertension.

Clinical of portal hypertension include those of chronic liver disease: , esophageal varices, , , and .

(2025). 9781859961643, Informa Healthcare.


Pulsatility
Portal vein pulsatility can be measured by Doppler ultrasonography. An increased pulsatility may be caused by , as well as increased right atrial pressure (which in turn may be caused by right or tricuspid regurgitation). Portal vein pulsatility can be quantified by pulsatility indices (PI), where an index above a certain cutoff indicates pathology:

+Pulsatility indices (PI) ! Index !! Calculation !! Cutoff
0.5
0.5 Page 367 in:
(2025). 9783540938422, Springer Science & Business Media.
- 0.54


Infection
is infection of the portal vein, usually arising from an infectious intra-abdominal process such as .


Portal venous gas
Hepatic portal venous gas is a rare finding on radiological exams. Gas is shown to enter the portal venous system. It is most commonly caused by intestinal ischemia but has also been associated with colon cancer.

==Additional images==

of the pig]]


External links
  • - "Stomach, Spleen and Liver: The Visceral Surface of the Liver"

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